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For a large number of experimental peptides, there are very limited pharmacology and toxicology data

"The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system." Journal of Pharmacology and Experimental Therapeutics

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Cagrilintide works through an entirely different receptor system

This suggests that long-term maintenance on an LD rich in carbohydrates may confound some of the microbiome differences commonly reported between mice on HFDs and those on lean control diets which contain fewer carbohydrates